Naringin Alleviates H2O2-Inhibited Osteogenic Differentiation of Human Adipose-Derived Stromal Cells via Wnt/β-Catenin Signaling. (29th April 2022)

• Record Type: Journal Article
• Authors: Yang, Xufang; Dong, Jianjiang; Hao, Yankun; Qi, Yucheng; Liang, Jun; Yan, Lei; Wang, Wenting
• Other Names: Garg Ruchika Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2022(2022)
• Publication Date: 2022-04-29
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2022/3126094
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Osteoporosis is an age-related systemic bone disease that places a heavy burden on patients and society. In this study, we aimed to investigate the effects of naringin (NAR) on the osteogenic differentiation of human adipose-derived stromal cells (ADSCs). The results demonstrated that NAR pretreatment effectively abated H2 O2 -induced cell death and ROS accumulation in ADSCs undergoing osteogenic differentiation (ADSCs-OD). In addition, we also observed that the impaired extracellular matrix mineralization and ALP activity in H2 O2 -stimulated ADSCs-OD were notably rescued by NAR pretreatment. Moreover, the effects of H2 O2 exposure on Wnt/ β -catenin signaling in ADSCs-OD were largely reversed by NAR pretreatment. Collectively, our findings indicated that NAR could protect ADSCs-OD against H2 O2 -inhibited osteogenic differentiation.