What Is the Therapeutic Reference Range for Levetiracetam? Grand Round/A Case Study. Issue 3 (June 2022)

• Record Type: Journal Article
• Authors: Couderc, Sylvain; Chouchane, Mondher; Saint-Marcoux, Franck
• Is Part Of: Therapeutic drug monitoring. Volume 44:Issue 3(2022)
• Page Start: 363
• Page End: 365
• Publication Date: 2022-06
• Subjects: levetiracetam -- therapeutic reference range -- steady-state trough concentration; Pharmacokinetics -- Periodicals; Patient monitoring -- Periodicals; Drugs -- Analysis -- Periodicals; Body fluids -- Analysis -- Periodicals; Drug Therapy -- Periodicals; Monitoring, Physiologic -- Periodicals; Pharmacology -- Periodicals; 615.7
• DOI: 10.1097/FTD.0000000000000972
• Languages: English
• ISSNs: 0163-4356

Abstract

Abstract: The Therapeutic Drug Monitoring guidelines of Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie had proposed a therapeutic reference range of 10–40 mg/L for levetiracetam in 2011. In the first version of the 2017 update, it was changed to 20–40 mg/L; however, 5 months later, in an erratum version, it was changed back to 10–40 mg/L. In this study, the authors agree with the range to 10–40 mg/L but discuss to what extent a wider interval may be proposed for certain patients.