Endocytic proteins: An expanding repertoire of presynaptic functions. (April 2022)

• Record Type: Journal Article
• Authors: Azarnia Tehran, Domenico; Maritzen, Tanja
• Is Part Of: Current opinion in neurobiology. Volume 73(2022)
• Publication Date: 2022-04
• Subjects: Neurobiology -- Periodicals; 573.8
• DOI: 10.1016/j.conb.2022.01.004
• Languages: English
• ISSNs: 0959-4388

Abstract

Abstract: From a presynaptic perspective, neuronal communication mainly relies on two interdependent events: The fast Ca 2+ -triggered fusion of neurotransmitter-containing synaptic vesicles (SVs) and their subsequent high-fidelity reformation. To allow rapid neurotransmission, SVs have evolved into fascinating molecular nanomachines equipped with a well-defined set of proteins. However, upon exocytosis, SVs fully collapse into the presynaptic plasma membrane leading to the dispersal of their molecular components. While the canonical function of endocytic proteins at the presynapse was believed to be the retrieval of SV proteins via clathrin-mediated endocytosis, it is now evident that clathrin-independent endocytic mechanisms predominate. We will highlight in how far these mechanisms still rely on the classical endocytic machinery and discuss the emerging functions of endocytic proteins in release site clearance and SV reformation from endosomal-like vacuoles. Highlights: Proteins involved in clathrin-mediated endocytosis play also a role in clathrin-independent internalization. Clathrin-associated adaptors also perform cargo sorting in clathrin-independent endocytosis. Endocytic proteins participate in the reformation of synaptic vesicles from endosomal-like vacuoles. Endocytic factors promote release site clearance.