Ameliorating effect of gum arabic on the liver tissues of the uremic rats; A biochemical and histological study. (June 2022)

• Record Type: Journal Article
• Authors: Fareed, Shimaa Antar; Almilaibary, Abdullah A.; Nooh, Hanaa Z.; Hassan, Shaimaa Mohamed
• Is Part Of: Tissue & cell. Volume 76(2022)
• Publication Date: 2022-06
• Subjects: Liver -- Uremia -- Gum Arabic -- Histopathology; Cytology -- Periodicals; 571.5
• DOI: 10.1016/j.tice.2022.101799
• Languages: English
• ISSNs: 0040-8166

Abstract

Abstract: Background: Gum Arabic (GA) has a protective role against experimental nephrotoxicity and hepatotoxicity. This study explores the possible ameliorating effect of Gum Arabic on the liver tissues of the uremic rats. Materials & methods: 50 adult male albino rats were divided into 5 groups; Group I, (negative control). Group II : two flank incisions were made and the kidneys were kindly manipulated. Group III : the rats have received a daily oral dose of GA. Group IV : subtotal nephrectomy in the left kidney was done followed by total nephrectomy on the right kidney 1 week later to induce uremia. Group V: the rats received GA one day after the second operation and daily for 5 weeks. At the end of the work, the rats were sacrificed, blood samples were collected for biochemical analysis. The abdomen was opened and the liver was dissected for light, electron microscopic and immunohistochemical studies. Results: The biochemical results were increased in the uremic group, but greatly improved after GA administration. Light and electron studies showed histopathological changes of the liver tissues in the uremic group, which was improved after GA administration and confirmed by the morphometric measures. Conclusion: GA ameliorates the histopathological changes of the liver tissues caused by uremic toxins and has a protective effect against the development of hepatocellular carcinoma. Highlights: Uremic toxins cause pathological changes in the liver tissues. Gum Arabic; as an antioxidant, contains antioxidant minerals and enzymes. Gum Arabic is a physiological modulator for a variety of body functions as cell proliferation, apoptosis, angiogenesis regulation, and inflammation. GA ameliorates the histopathological changes in the liver tissues.