Enantioselective characteristics, bioaccumulation and toxicological effects of chlordane-related compounds in laying hens. (August 2022)

• Record Type: Journal Article
• Authors: Liu, Xueke; Wang, Peng; Liang, Yiran; Zhan, Jing; Liu, Donghui; Zhou, Zhiqiang
• Is Part Of: Chemosphere. Volume 300(2022)
• Publication Date: 2022-08
• Subjects: Chlordane -- Laying hens -- Enantioselectivity -- Maternal transfer; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.134486
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Chlordane-related compounds are ubiquitously detected in the environment and can transfer and accumulate to animals through food chain to cause adverse effects. In this study, the dynamic distribution and the enantiomeric profile of chlordane-related compounds in laying hens over time were investigated. The effect of these compounds on immune-associated cells in the intestinal tract and histopathology in some tissues were also evaluated after long-term exposure. The chlordane-related compounds preferentially accumulated in fat, followed by the intestines, ovum, and egg yolk during long-term exposure. The metabolites heptachlor epoxide and oxychlordane were mainly formed in the liver of hens by epoxidation or hydroxylation. The high accumulation ratios of trans -nonachlor and MC5 were found in ovum and egg yolk after long-term exposure, implying a greater risk to the hens' offspring. Chlordane-related compounds may cause abnormal lipometabolism and glycometabolism in liver of hens. Additionally, (−)-Cis-chlordane was dominant in all tissues of laying hens and its dominance increased over time. Conversely, (+)-isomer of metabolite oxychlordane was overwhelmingly dominant during the experiment. These findings about enantioselectivity, metabolic processes and toxicological effects are crucial in understanding the exposure risk of chlordane-related compounds. Graphical abstract: Image 1 Highlights: Distribution of chlordane-related compounds were systematically studied in hens. The high accumulation ratios of TN and MC5 were found in ovum and egg yolk. Enantiomeric profiles of chlordane-related compounds were investigated. (−)-Cis-chlordane and (+)-oxychlordane was dominant. Immune-associated cells and histopathology were evaluated.