Pregnancy outcomes after fresh versus vitrified-warmed embryo transfer in women with adenomyosis: a retrospective cohort study. Issue 6 (June 2022)

• Record Type: Journal Article
• Authors: Zhu, Xingwang; Dongye, Houjin; Lu, Shaoming; Zhao, Xingbo; Yan, Lei
• Is Part Of: Reproductive biomedicine online. Volume 44:Issue 6(2022)
• Page Start: 1023
• Page End: 1029
• Publication Date: 2022-06
• Subjects: Adenomyosis -- Fresh embryo transfer -- Single live birth -- Vitrified-warmed embryo transfer; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2022.02.013
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: Research question: Is the singleton live birth rate superior for vitrified-warmed versus fresh embryo transfer in women with adenomyosis? Design: This cohort study retrospectively analysed data from the Reproductive Hospital Affiliated to Shandong University between January 2013 and December 2018. A total of 612 women diagnosed with adenomyosis, with 322 fresh embryo transfer cycles and 290 vitrified-warmed embryo transfer cycles, were included in this study. The primary outcome was singleton live birth. Outcomes were adjusted using multivariable logistic regression analysis. Results: Vitrified-warmed embryo transfer was associated with a higher rate of singleton live birth than fresh embryo transfer (25.9% versus 17.4%; P = 0.011). Although there was a trend towards a lower miscarriage rate after vitrified-warmed embryo transfer, the difference did not reach statistical significance (31.3% versus 40.6%; P = 0.111). The clinical pregnancy rate was comparable in the two groups (44.1% versus 44.4%; P = 0.946). Vitrified-warmed embryo transfer also resulted in a lower risk of preterm birth than fresh embryo transfer (7.0% versus 17.5%; P = 0.010). Conclusions: Vitrified-warmed embryo transfer may be associated with better pregnancy outcomes than fresh embryo transfer among women with adenomyosis. It seems that vitrified-warmed embryo transfer is more appropriate for specific populations.