Non‐aggregated and water soluble axially disubstituted silicon phthalocyanines: Synthesis and inhibitory effect on acetylcholinesterase enzyme. (20th March 2022)

• Record Type: Journal Article
• Authors: Biyiklioglu, Zekeriya; Baş, Huseyin; Sahin, Huseyin
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-20
• Subjects: acetylcholinesterase -- Alzheimer's disease -- phthalocyanine -- silicon -- water solubility; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6668
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract: In this study, axially pyridine groups substituted silicon (IV) phthalocyanines (3PY‐7‐Si and 3PY‐8‐Si ) and their water soluble derivatives 3PY‐7a‐SiQ and 3PY‐8a‐SiQ were synthesized and acetylcholinesterase inhibition properties were examined. Axially pyridine groups substituted silicon (IV) phthalocyanines (3PY‐7‐Si and 3PY‐8‐Si ) and their water soluble derivatives 3PY‐7a‐SiQ and 3PY‐8a‐SiQ showed the various degrees of acetylcholinesterase inhibition activity. Their IC50 values causing 50% inhibition of the enzyme were ranged between 0.598 ± 0.068 and 0.886 ± 0.016 mM which 3PY‐7a‐SiQ was the best. These results demonstrated that the compounds might be effective agents against Alzheimer's disease. Abstract : Synthesis of axially disubstituted silicon phthalocyanines. Synthesis of silicon phthalocyanines. Investigation of acetylcholinesterase inhibition properties of silicon phthalocyanines.