Synthesis, spectroscopic, CO‐releasing ability, and anticancer activity studies of [Mn(CO)3(L–L)Br] complexes: Experimental and density functional theory studies. (9th April 2022)

• Record Type: Journal Article
• Authors: Thomas, Jisha Mary; Vidhyapriya, Pitchavel; Sivan, Akhil K.; Sakthivel, Natarajan; Sivasankar, Chinnappan
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-09
• Subjects: CO‐releasing molecules -- photoCORM -- myoglobin assay -- DFT/TD‐DFT -- MTT assay; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6685
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract: Two different series of manganese(I) tricarbonyl complexes containing phosphine‐based (1 –5 ) and 4′‐substituted 2, 2′:6′, 2″‐terpyridine‐based ligands (6 –10 ) have been synthesized in order to study their CO‐releasing ability and to investigate their anticancer activity. All the synthesized complexes (1 –10 ) have been fully characterized using standard spectroscopic and analytical techniques. Further 5, 7, and 9 have also been characterized by single‐crystal X‐ray diffraction studies. Although both the sets of ligands are π ‐acceptors, they tend to change the Mn—CO bond strength upon complexation, thus affecting the CO release. Photoactivation of 1 –5 and 6 –10 has been achieved using 365 nm UV irradiation and low intensity visible light, respectively. The MnCO bond strength has been examined using the density functional theory (DFT) and time‐dependent DFT (TD‐DFT) calculations. In order to find the therapeutic viability of the visible light activated complexes, their cytotoxicity has been investigated both in the dark and under irradiation. The MTT (3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyl tetrazolium bromide) assay reveals the potential application of some of the synthesized complexes especially towards the lung cancer cells in the dark condition. Abstract : The synthesis and characterization of two sets of Mn(I) tricarbonyl complexes stabilized by phosphine‐based and 4′‐substituted‐2, 2′:6′, 2″‐terpyridine‐based ligands are reported, in order to study the effect of these chelating ligands on the Mn carbonyl bonding and subsequently on their CO‐releasing ability. Theoretical investigations related to bonding nature of these complexes are also reported. The anticancer activity of the complexes is also investigated using the MTT assay against lung, colon and cervical cancer cells.