Clinical valuation of ST changes in a group of patients with ventricular arrhythmias: The inSighT Study. Issue 3 (15th February 2022)

• Record Type: Journal Article
• Authors: Wranicz, Jerzy Krzysztof; Kałowski, Michał; Bastian, Dirk; Jaswal, Aparna; Kolb, Christof; Zitron, Edgar; Cygankiewicz, Iwona; Kaczmarek, Krzysztof
• Is Part Of: Annals of noninvasive electrocardiology. Volume 27:Issue 3(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-15
• Subjects: implantable cardioverter–defibrillator -- intracardiac electrocardiograms -- ST‐segment changes -- ventricular fibrillation -- ventricular tachycardia; Electrocardiography -- Periodicals; Arrhythmia -- Periodicals; 616.1207547
• DOI: 10.1111/anec.12914
• Languages: English
• ISSNs: 1082-720X

Abstract

Abstract: Background: The inSighT study was designed to determine the prevalence of ischemic changes as recorded by implantable cardioverter–defibrillator (ICD) ST deviations in intracardiac electrocardiograms (EGM) over the 24 h preceding malignant ventricular arrhythmias (VT/VF). Methods: The study enrolled patients with known coronary artery disease (CAD) or high risk of future development of CAD implanted with an ICD equipped with an ST monitoring feature (Ellipse™/Fortify Assura™, St. Jude Medical). Device session records were collected at each in‐clinic follow‐up. EGM ST levels of the beats over the 15 minutes prior to VT/VF events were compared using a t test with those from a baseline period of 23–24 h prior to the VT/VF event. All events with p < .05 were visually inspected to confirm they were evaluable; additional criteria for exclusion from further analysis included inappropriate therapy, aberrant conduction, and occurrence of VT/VF within 24h prior to the current event. Results: The study enrolled 481 ICD patients (64 ± 11 years, 83% male) in 14 countries and followed them for 15±5 months. A total of 165 confirmed VT/VF episodes were observed, of which 71 events (in 56 patients, 34% of all patients with VT/VF) were preceded by significant ( p < .05) ST‐segment changes unrelated to known non‐ischemic causes. None of the analyzed demographic and clinical factors proved to be associated with greater odds of presenting with ST‐segment changes prior to VT/VF episode. Conclusion: In this exploratory study, characteristic ST‐segment changes, likely representative of ischemic events, were observed in 34% of all patients with VT/VF episodes. Abstract : Analysis of VT/VF events and preceding ST‐segment changes.