Suzuki–Miyaura arylation of 2, 3‐, 2, 4‐, 2, 5‐, and 3, 4‐dibromothiophenes. (10th March 2022)

• Record Type: Journal Article
• Authors: Baran, Andrei; Babkova, Mariia; Petkus, Jana; Shubin, Kirill
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-10
• Subjects: boronic acids -- dibromothiophenes -- green solvent -- palladium catalysis -- Suzuki–Miyaura reaction; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6653
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : A convenient and general method for Suzuki–Miyaura double cross‐coupling of various dibromothiophenes was developed. Using a simple and cheap catalytic system Pd(OAc)2 /PPh3 in 95% EtOH, various (hetero)arylboronic acids react with dibromothiophenes providing diarylthiophenes, useful in the synthesis of metal–organic frameworks (MOFs), in moderate to excellent yields. The overall efficiency of the catalytic process and slight excess of boronic acids allowed to suppress formation of side products and significantly simplify the purification of products. Abstract :