Spindle‐Like Zinc Silicate Nanoparticles Accelerating Innervated and Vascularized Skin Burn Wound Healing. Issue 10 (9th February 2022)

• Record Type: Journal Article
• Authors: Zhang, Hongjian; Ma, Wenping; Ma, Hongshi; Qin, Chen; Chen, Jiajie; Wu, Chengtie
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-09
• Subjects: innervation -- nanofibrous scaffolds -- skin burn wound healing -- vascularization -- zinc silicate; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202102359
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: The treatment of severe burn injuries is a crucial challenge in skin tissue engineering. Severe burns are always accompanied with large‐area neurovascular networks damage, leading to the lack of excitation functions and difficulty in self‐healing. Therefore, it is of great importance to develop biomaterials which can not only promote wound healing but also simultaneously reconstruct cutaneous neurovascular networks. In this study, Zn2 SiO4 (ZS) nanoparticles‐incorporated bioactive nanofibrous scaffolds are designed for innervated and vascularized skin burn wound healing. ZS nanoparticles with spindle‐like morphology are synthesized via a facile hydrothermal method. The incorporation of ZS nanoparticles endows the scaffolds with excellent angiogenic and neurogenic activities in vitro. Additionally, in vivo results show that the ZS nanoparticles‐incorporated scaffolds have favorable re‐epithelialization, innervation, and vascularization abilities through local release of bioactive Zn and Si ions from ZS nanoparticles, leading to rapid wound healing featuring with newly formed blood vessels and nerve fibers. Taken together, this study suggests that the spindle‐like ZS nanoparticles are useful bioactive agents for stimulating vascularization and innervation of functional skin repair. The bioactive inorganic nanoparticles may be used for multifunctional tissue regeneration. Abstract : Spindle‐like zinc silicate nanoparticles are synthesized via hydrothermal method and then incorporated into nanofibrous scaffolds to serve as bioactive factors. Due to the sustained release of bioactive Zn and Si ions, zinc silicate nanoparticles‐based multifunctional scaffolds can not only accelerate the healing process of deep second‐degree burn wounds but also reconstruct the damaged neurovascular networks.