Tobacco smoking and solid fuels for cooking and risk of liver cancer: A prospective cohort study of 0.5 million Chinese adults. Issue 2 (3rd March 2022)

• Record Type: Journal Article
• Authors: Wen, Qiaorui; Chan, Ka Hung; Shi, Kexiang; Lv, Jun; Guo, Yu; Pei, Pei; Yang, Ling; Chen, Yiping; Du, Huaidong; Gilbert, Simon; Avery, Daniel; Hu, Weijie; Chen, Junshi; Yu, Canqing; Chen, Zhengming; Li, Liming
• Is Part Of: International journal of cancer. Volume 151:Issue 2(2022)
• Page Start: 181
• Page End: 190
• Publication Date: 2022-03-03
• Subjects: liver cancer -- prospective cohort study -- solid fuel -- tobacco smoking; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.33977
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract: Previous research found tobacco smoking and solid fuel use for cooking to increase the risk of chronic liver disease mortality, but previous cohort studies have not investigated their independent and joint associations with liver cancer incidence in contemporary China. The China Kadoorie Biobank (CKB) study recruited 0.5 million adults aged 30 to 79 years from 10 areas across China during 2004 to 2008. Participants reported detailed smoking and fuel use information at baseline. After an 11.1‐year median follow‐up via electronic record linkage, we recorded 2997 liver cancer cases. Overall, 29.4% participants were current smokers. Among those who cooked at least once per month, 48.8% always used solid fuels (ie, coal or wood) for cooking. Tobacco smoking and solid fuel use for cooking were independently associated with increased risks of liver cancer, with hazard ratios (95% confidence intervals [CIs]) of 1.28 (1.15‐1.42) and 1.25 (1.03‐1.52), respectively. The more cigarettes consumed each day, the earlier the age of starting smoking or the longer duration of solid fuels exposure, the higher the risk ( P trend < .001, =.001, = .018, respectively). Compared with never smokers who had always used clean fuels (ie, gas or electricity), ever‐smokers who had always used solid fuels for cooking had a 67% (95% CIs: 1.29‐2.17) higher risk. Among Chinese adults, tobacco smoking and solid fuel use for cooking were independently associated with higher risk of liver cancer incidence. Stronger association was observed with higher number of daily cigarette consumption, the earlier age of starting smoking and longer duration of solid fuel use. Abstract : What's new? Tobacco smoking and cooking with solid fuels, such as coal or wood, increase the risk of death from chronic liver disease. Here, the authors investigated whether these factors might also drive liver cancer incidence. They recruited 500 000 adults from different regions of China and recorded their smoking and fuel use data at baseline. Over a median follow‐up of 11 years, they recorded nearly 3000 liver cancer cases. Smoking and cooking with solid fuels were independently associated with higher risk of liver cancer incidence, with longer duration of exposure associated with a larger increase in risk.