Engineered Exosomes as a Photosensitizer Delivery Platform for Cancer Photodynamic Therapy. (22nd April 2022)

• Record Type: Journal Article
• Authors: Dao, Anyi; Kushwaha, Rajesh; Kumar, Ashish; Huang, Huaiyi; Banerjee, Samya
• Is Part Of: ChemMedChem. Volume 17:Number 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-22
• Subjects: Engineered exosomes -- Photosensitizer delivery -- Photodynamic therapy -- Anti-tumor agents; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.202200119
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract: Photodynamic therapy (PDT), a non‐/minimally invasive cancer treatment method, has the advantages of low side effects, high selectivity, and low drug resistance. It is currently a popular cancer treatment method. However, given the shortcomings of photosensitizers such as poor photostability, poor water solubility, and short half‐life in vivo when used alone, the development of photosensitizer nano‐delivery platforms has always been a research hotspot to overcome these shortcomings. In the human body, various types of cells generally release bilayer extracellular vesicles known as exosomes. Compared with traditional materials, exosomes are currently an ideal drug delivery platform due to their homology, low immunogenicity, easy modification, high biocompatibility, and natural carrying capacity. Therefore, in this concept, we focus on the research status and prospects of engineered exosome‐based photosensitizer nano‐delivery platforms in cancer PDT. Abstract : Engineered exosomes have the potential to provide targeted delivery of photosensitizers for the photodynamic treatment of cancer. This delivery system takes advantage of exosomes released by various types of cells in the human body and shows promise for various targeted drug delivery regimes. This approach therefore warrants thorough investigation.