Extensive myelitis with eosinophilic meningitis after Chimeric antigen receptor T cells therapy. Issue 2 (1st February 2022)

• Record Type: Journal Article
• Authors: Le Calvez, Baptiste; Eveillard, Marion; Decamps, Paul; Aguilar, Jesus; Seguin, Amélie; Canet, Emmanuel; Grain, Audrey; Touzeau, Cyrille; Tessoulin, Benoît; Gastinne, Thomas
• Is Part Of: EJHaem. Volume 3:Issue 2(2022)
• Page Start: 533
• Page End: 536
• Publication Date: 2022-02-01
• Subjects: Chimeric antigen receptor T cells -- eosinophilic meningitis -- eosinophilic pleocytosis -- mantle cell lymphoma -- myelitis; Hematology -- Periodicals; 616.15
• DOI: 10.1002/jha2.381
• Languages: English
• ISSNs: 2688-6146

Abstract

Abstract: Immune effector cell‐associated neurotoxicity syndrome (ICANS) is a frequent adverse event after Chimeric antigen receptor T cells (CAR‐T cells). A patient treated with anti‐CD19 CAR‐T cells for a refractory mantle cell lymphoma presented at Day 8 post‐infusion with extensive myelitis. Unusual eosinophilia was disclosed in the patient's cerebrospinal fluid. After treatment with methylprednisolone and siltuximab, a decrease in clinical symptoms and magnetic resonance imaging lesions were obtained. This unprecedented presentation of eosinophilic meningitis after CAR‐T cells therapy highlights the need for a better understanding of the physiopathology of ICANS, especially to identify potentially targetable pathways.