Metabolite selection for machine learning in childhood brain tumour classification. (27th January 2022)

• Record Type: Journal Article
• Authors: Zhao, Dadi; Grist, James T.; Rose, Heather E.L.; Davies, Nigel P.; Wilson, Martin; MacPherson, Lesley; Abernethy, Laurence J.; Avula, Shivaram; Pizer, Barry; Gutierrez, Daniel R.; Jaspan, Tim; Morgan, Paul S.; Mitra, Dipayan; Bailey, Simon; Sawlani, Vijay; Arvanitis, Theodoros N.; Sun, Yu; Peet, Andrew C.
• Is Part Of: NMR in biomedicine. Volume 35:Number 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-27
• Subjects: childhood brain tumour -- machine learning -- metabolite concentration -- MRS -- multi‐class classification -- receiver operating characteristics; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.4673
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract : MRS can provide high accuracy in the diagnosis of childhood brain tumours when combined with machine learning. A feature selection method such as principal component analysis is commonly used to reduce the dimensionality of metabolite profiles prior to classification. However, an alternative approach of identifying the optimal set of metabolites has not been fully evaluated, possibly due to the challenges of defining this for a multi‐class problem. This study aims to investigate metabolite selection from in vivo MRS for childhood brain tumour classification. Multi‐site 1.5 T and 3 T cohorts of patients with a brain tumour and histological diagnosis of ependymoma, medulloblastoma and pilocytic astrocytoma were retrospectively evaluated. Dimensionality reduction was undertaken by selecting metabolite concentrations through multi‐class receiver operating characteristics and compared with principal component analysis. Classification accuracy was determined through leave‐one‐out and k ‐fold cross‐validation. Metabolites identified as crucial in tumour classification include myo ‐inositol ( P < 0.05, AUC = 0 . 81 ± 0 . 01 ), total lipids and macromolecules at 0.9 ppm ( P < 0.05, AUC = 0 . 78 ± 0 . 01 ) and total creatine ( P < 0.05, AUC = 0 . 77 ± 0 . 01 ) for the 1.5 T cohort, and glycine ( P < 0.05, AUC = 0 . 79 ± 0 . 01 ), total N ‐acetylaspartate ( P < 0.05, AUC = 0 . 79 ± 0 . 01 ) and total choline ( P < 0.05, AUC = 0 . 75 ± 0 . 01 ) for the 3 T cohort. Compared with the principal components, the selected metabolites were able to provide significantly improved discrimination between the tumours through most classifiers ( P < 0.05). The highest balanced classification accuracy determined through leave‐one‐out cross‐validation was 85% for 1.5 T 1 H‐MRS through support vector machine and 75% for 3 T 1 H‐MRS through linear discriminant analysis after oversampling the minority. The study suggests that a group of crucial metabolites helps to achieve better discrimination between childhood brain tumours. Abstract : Metabolite selection is introduced as a new feature selection method for childhood brain tumour classification through machine learning and proton MRS. Metabolites are selected based on their diagnostic ability across multiple tumour types. Robustly improved classification accuracy suggests metabolite selection as a potentially better feature extraction approach.