Microbiota‐microglia connections in age‐related cognition decline. Issue 5 (29th March 2022)

• Record Type: Journal Article
• Authors: Zhou, Rui; Qian, Shufang; Cho, William C. S.; Zhou, Jinyun; Jin, Chentao; Zhong, Yan; Wang, Jing; Zhang, Xiaohui; Xu, Zhoujiao; Tian, Mei; Chan, Lawrence W. C.; Zhang, Hong
• Is Part Of: Aging cell. Volume 21:Issue 5(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-29
• Subjects: cognitive aging -- gut microbiota -- microglia -- neuroinflammation; Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.13599
• Languages: English
• ISSNs: 1474-9718

Abstract

Abstract: Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging‐induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut‐brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age‐related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age‐related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota‐microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease). Abstract : Microbiota‐microglia connection has been recognized in recent years. Aging‐induced changes of gut microbiota composition have a critical role in mediating the morphology and functions of microglia through gut‐brain axis, which is tightly related to age‐related cognitive decline. Here, we review the age‐related changes of gut microbiota and brain, and highlight the interaction between microbiota and microglia in the aged brain.