Non‐coding RNAs in Kawasaki disease: Molecular mechanisms and clinical implications. (31st March 2022)

• Record Type: Journal Article
• Authors: Yang, Fuqing; Ao, Xiang; Ding, Lin; Ye, Lin; Zhang, Xuejuan; Yang, Lanting; Zhao, Zhonghao; Wang, Jianxun
• Is Part Of: BioEssays. Volume 44:Number 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-31
• Subjects: circRNA -- endothelial dysfunction -- immune dysfunction -- inflammatory disorder -- Kawasaki disease -- lncRNA -- miRNA; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.202100256
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract: Kawasaki disease (KD) is an acute self‐limiting vasculitis with coronary complications, usually occurring in children. The incidence of KD in children is increasing year by year, mainly in East Asian countries, but relatively stably in Europe and America. Although studies on KD have been reported, the pathogenesis of KD is unknown. With the development of high‐throughput sequencing technology, growing number of regulatory noncoding RNAs (ncRNAs) including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) have been identified to involved in KD. However, the role of ncRNAs in KD has not been comprehensively elucidated. Therefore, it is significative to study the regulatory role of ncRNA in KD, which might help to uncover new and effective therapeutic strategies for KD. In this review, we summarize recent studies on ncRNA in KD from the perspectives of immune disorders, inflammatory disorders, and endothelial dysfunction, and highlight the potential of ncRNAs as therapeutic targets for KD. Abstract : Non‐coding RNA can regulate the development of Kawasaki disease from immune disorders, inflammatory disorders and endothelial dysfunction. Among them, protective non‐coding RNA can inhibit the occurrence of Kawasaki disease, while interfering non‐coding RNA promote its occurrence.