Analysis of factors influencing patch test reactions: Results from a large‐ population‐based study in Chinese. (22nd July 2021)

• Record Type: Journal Article
• Authors: Li, Bingjie; Cheng, Ying; Tan, Yimei; Wang, Fudi; Hu, Weiyi; Wang, Xuemin; Liu, Wei; Krutmann, Jean; Wang, Sijia; Zou, Ying
• Is Part Of: Journal of cosmetic dermatology. Volume 21:Number 5(2022)
• Page Start: 2183
• Page End: 2188
• Publication Date: 2021-07-22
• Subjects: influencing factors -- patch test to cosmetics -- skin reactions; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.14338
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: Patch test, as a helpful tool in clinic diagnosis and safety assessment of cosmetics, is affected by many factors. Objectives: To investigate the influencing factors of patch test reactions in a highly standardized large‐scale dataset of Chinese. Methods: Patch test data ( n = 151, 280) from safety assessments of cosmetic products were obtained following internationally standardized patch testing protocols during 2004–2017 in China. Results: The frequency of patch test reactions was 1.45% (2, 191/151, 280), with majority of the reactions being "score 1" reactions (also known as doubtful reactions, n = 2, 075) and a small number being "score 2" reactions (weak reactions, n = 116). Patch test reactions were 67% more frequent in winter ( p < 0.001), associated with temperatures ( p < 0.001), rather than relative humidity (P:0.29). The frequency of reactions was higher in men than in women ( p :0.001), especially in winter. The risk to develop reactions clearly increased with age in women ( p < 0.001), but not in men ( p :0.14). In women, the frequency of reactions in the old group (≥50 years old) was 30% more than the young group (<30 years old). Conclusions: The frequency of patch test reactions to cosmetic products was 1.45% in our large‐scale study. The influencing factors of patch test include season, sex, and age, which should be considered when conducting and interpreting patch testing.