Regulated Exogenous/Endogenous Inflammation via "Inner‐Outer" Medicated Electrospun Fibers for Promoting Tissue Reconstruction. Issue 10 (14th January 2022)

• Record Type: Journal Article
• Authors: Zhou, Xue; Saiding, Qimanguli; Wang, Xianjing; Wang, Juan; Cui, Wenguo; Chen, Xinliang
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-14
• Subjects: core–shell fibers -- electrospinning -- inflammation -- surface modification -- tissue reconstruction; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202102534
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Regenerative medicine aims to provide solutions for structural and functional recovery in conditions where organs suffer from varying degrees of diseases or injuries. However, the exogenous inflammation triggered by implanted biomaterials and endogenous inflammation caused by some disease or tissue destruction has not been solved properly yet. Herein, a functional "inner‐outer" medicated core–shell electrospun fibrous membrane is fabricated with RGD surface modification for exogenous inflammation suppression and puerarin loading in the core for long‐term endogenous inflammation inhibition through microsol electrospinning technique. The "outer" RGD significantly increases biocompatibility of fibrous membrane through promoting cell viability, adhesion, and proliferation while the "inner" puerarin suppresses inflammatory gene expression via sustained drug release in vitro. Moreover, in a rat abdominal wall hernia model, the functional fibrous membrane successfully reduces exogenous and endogenous inflammation response and promotes wound healing through collagen deposition, smooth muscle formation, and vascularization. In summary, the functional "inner‐outer" medicated fibrous membrane holds a great potential for clinical treatment of diseases that needs tissue reconstruction structurally and functionally accompanied by immunoregulation. Abstract : The functional "outer‐inner" medicated electrospun fibrous membrane is fabricated through microsol electrospinning and surface modification, which is a "killing two birds with one stone" strategy for regulating exogenous and endogenous inflammation. The "outer‐inner" medicated fibrous membrane efficiently regulates early exogenous and long‐term endogenous inflammation for promoted collagen deposition, neovascularization, and smooth muscle formation.