Competition between epithelial tissue elasticity and surface tension in cancer morphogenesis. (1st June 2022)

• Record Type: Journal Article
• Authors: Favata, Antonino; Paroni, Roberto; Recrosi, Filippo; Tomassetti, Giuseppe
• Is Part Of: International journal of engineering science. Volume 176(2022)
• Publication Date: 2022-06-01
• Subjects: Epithelium -- Subcritical bifurcation -- Surface energy -- Cancer morphogenesis -- Rod theories -- Cell elasticity; Engineering -- Periodicals; Ingénierie -- Périodiques; Engineering; Periodicals; 620
• DOI: 10.1016/j.ijengsci.2022.103677
• Languages: English
• ISSNs: 0020-7225

Abstract

Abstract: We derive a continuum mechanical model to capture the morphological changes occurring at the pretumoral stage of epithelial tissues. The proposed model aims to investigate the competition between the bulk elasticity of the epithelium and the surface tensions of the apical and basal sides. According to this model, when the apico-basal tension imbalance reaches a critical value, a subcritical bifurcation is triggered and the epithelium attains its physiological folded shape. Based on data available in the literature, our model predicts that pretumoral cells are softer than healthy cells.