Clinical features and diagnostic tools in idiopathic inflammatory myopathies. (19th May 2022)

• Record Type: Journal Article
• Authors: Tsamis, Konstantinos I.; Boutsoras, Constantinos; Kaltsonoudis, Evripidis; Pelechas, Eleftherios; Nikas, Ilias P.; Simos, Yannis V.; Voulgari, Paraskevi V.; Sarmas, Ioannis
• Is Part Of: Critical reviews in clinical laboratory sciences. Volume 59:Number 4(2022)
• Page Start: 219
• Page End: 240
• Publication Date: 2022-05-19
• Subjects: Polymyositis (PM) -- dermatomyositis (DM) -- sporadic inclusion body myositis (sIBM) -- immune-mediated necrotizing myopathy (IMNM) -- antisynthetase syndrome (ASS); Diagnosis, laboratory -- Periodicals; Medicine, Clinical -- Periodicals; 616.07
• DOI: 10.1080/10408363.2021.2000584
• Languages: English
• ISSNs: 1040-8363

Abstract

Abstract: Idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders affecting primarily muscles, but other organs can be involved. This review describes the clinical features, diagnosis and treatment for IIMs, namely polymyositis (PM), dermatomyositis (DM), sporadic inclusion body myositis (sIBM), immune-mediated necrotizing myopathy (IMNM), and myositis associated with antisynthetase syndrome (ASS). The diagnostic approach has been updated recently based on the discovery of circulating autoantibodies, which has enhanced the management of patients. Currently, validated classification criteria for IIMs allow clinical studies with well-defined sets of patients but diagnostic criteria to guide the care of individual patients in routine clinical practice are still missing. This review analyzes the clinical manifestations and laboratory findings of IIMs, discusses the efficiency of modern and standard methods employed in their workup, and delineates optimal practice for clinical care. Α multidisciplinary diagnostic approach that combines clinical, neurologic and rheumatologic examination, evaluation of electrophysiologic and morphologic muscle characteristics, and assessment of autoantibody immunoassays has been determined to be the preferred approach for effective management of patients with suspected IIMs.