Per- and polyfluoroalkyl substances (PFASs) in the blood of police and Beagle dogs from Harbin, China: Concentrations and associations with hematological parameters. (July 2022)

• Record Type: Journal Article
• Authors: You, Dan; Chang, Xiaochen; Guo, Lijun; Xie, Wei; Huang, Shuping; Li, Xiang; Chai, Hongliang; Wang, Yajun
• Is Part Of: Chemosphere. Volume 299(2022)
• Publication Date: 2022-07
• Subjects: PFAS -- Bioaccumulation -- Dogs -- Biochemical parameters; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.134367
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Per-and polyfluoroalkyl substances (PFASs) have been omnipresent in the environment and marine organisms. However, little is known about these compounds and their associations with hematological parameters in dogs. In this research, we investigated the concentrations and distributions of PFASs in the blood of dogs and explored the associations between PFASs concentrations in blood and hematological parameters. Perfluorooctanoate (PFOA) was found to be the dominant PFAS in the blood (54.23%), followed by perfluorobutyric acid (PFBA) (16.05%) and perfluorooctanesulfonate (PFOS) (12.05%). On average, PFASs concentration in dogs was 3.553 ng/mL (SD: 2.146). Moreover, age is a key factor influencing the levels of PFBA, PFOA, and PFBS in males, as well as seven PFASs (6:2 Cl-PFESA, PFBA, PFOA, PFOS, PFHxS, PFDA, and PFNA) in female dogs' blood. The results revealed that PFHxS in dietary food accounted for most of the total daily PFASs consumption. We also discovered that greater PFASs exposure (including PFOA and PFOS) could significantly increase amylase (AMY) and decrease cholesterol (CHOL) levels. Furthermore, there are linear relationships between PFDA, PFNA and many biochemical parameters (AMY, CHOL, albumin/globulin (A/G), blood urea nitrogen (BUN), alkaline phosphatase (ALP), creatinine (CREA)). Thus, PFAS accumulation has a certain influence on dogs' health, and we must pay attention to the potential threat posed by these elements to dogs. Graphical abstract: Image 1 Highlights: 13 PFAS were detected in the blood of police dogs for the first time. PFOA was the predominant PFAS, followed by PFBA and PFOS. Dietary food was not the predominant PFASs exposure pathway. PFASs were related to hematological parameters in the dogs for the first time. Greater PFOA and PFOS could significantly increase AMY and decrease CHOL levels.