A Metal Free, Hantzsch Synthesis for Privileged Scaffold 1, 4-Dihydropyridines: A Glycerol Promoted Sustainable Protocol. (21st April 2022)

• Record Type: Journal Article
• Authors: Tiwari, Saurabh K.; Shivhare, Km Neha; Patel, Manoj K.; Yadav, Vikas; Nazeef, Mohd; Siddiqui, I. R.
• Is Part Of: Polycyclic aromatic compounds. Volume 42:Number 4(2022)
• Page Start: 1035
• Page End: 1047
• Publication Date: 2022-04-21
• Subjects: 1, 4-dihydropyridines -- privileged sacffolds -- Hantzsch synthesis -- metal free -- glycerol promoted -- green synthesis; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2020.1764988
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: An eco-compatible, facile and clean strategy for the synthesis of 1, 4-dihydropyridine (1, 4-DHP) derivatives has been reported through one pot multi-component Hantzsch reaction using glycerol as a promoting medium. A nontoxic and cheap by-product of biodiesel industry i.e., glycerol has been utilized as a reaction condition in our protocol. The reported protocol offers a greener, economical and expeditious synthesis of biologically significant 1, 4-DHPs with moderate to excellent yields with high atom economy under metal free mild reaction conditions. In addition, operational simplicity, cost effectiveness, and reusability are the additional advantages of our protocol with the avoidance of hazardous volatile solvents. Graphical Abstract: