A Simple and Efficient One-Pot Route for the Synthesis of 3-[1-Aryl(Alkyl)-2-Pyridin-2-yl-Ethyl]-4-Hydroxy-6-Methyl-2H-Pyran-2-Ones under Catalyst-Free Conditions. (21st April 2022)

• Record Type: Journal Article
• Authors: Hoseinpour, Mahdieh; Mohebat, Razieh; Nateghi, Mohammad Reza; Kalantari Fotooh, Forough
• Is Part Of: Polycyclic aromatic compounds. Volume 42:Number 4(2022)
• Page Start: 1879
• Page End: 1884
• Publication Date: 2022-04-21
• Subjects: 2-Methylpyridine -- 3-[1-aryl(alkyl)-2-pyridin-2-yl-ethyl]-4-hydroxy-6-methyl-2H-pyran-2-ones -- 4-Hydroxy-6-methyl-2H-pyran-2-one -- aldehydes -- catalyst-free conditions; Polycyclic aromatic compounds -- Periodicals; 547
• DOI: 10.1080/10406638.2020.1815812
• Languages: English
• ISSNs: 1040-6638

Abstract

Abstract: Reaction between 4-hydroxy-6-methyl-2H-pyran-2-one and aldehydes with 2-methylpyridine in dioxane under catalyst-free conditions provided a simple and efficient one-pot route for the synthesis of 3-[1-aryl(alkyl)-2-pyridin-2-yl-ethyl]-4-hydroxy-6-methyl-2H-pyran-2-ones. The reaction is characterized by inexpensive and easily available starting materials, the formation of a single product, high yields of biologically active products, and a simple work-up process. Graphical Abstract: