Eight undescribed steroidal saponins including an unprecedented 16, 26-epoxy-furostanol saponin from Solanum xanthocarpum and their cytotoxic activities. (July 2022)

• Record Type: Journal Article
• Authors: Xu, Zhen-Peng; Liu, Yan; Wang, Si-Yi; Li, Zi-Wei; Li, Xiao-Mao; Lu, Dong-Xu; Pan, Juan; Kuang, Hai-Xue; Yang, Bing-You
• Is Part Of: Phytochemistry. Volume 199(2022)
• Publication Date: 2022-07
• Subjects: Solanum xanthocarpum -- Solanaceae -- Sterides -- Steroidal glycosides -- 16, 26-Epoxy-furostanol saponin -- Solasaponin; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113171
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Eight undescribed steroidal saponins named solasaponins A-H were isolated from the fruits of Solanum xanthocarpum, including an unusual 16, 26-epoxy-furostanol saponin, two furostanol saponins, three isospirostanol saponins, two pseudo-spirostanol saponins. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HRESIMS) combined with physico-chemical analysis methods (acid hydrolysis, optical rotation, and IR). The cytotoxicities of all compounds in vitro against two human cancer cell lines (A-549 and HepG2) were evaluated by CCK-8 assay. Graphical abstract: Image 1 Highlights: Eight undescribed steroidal saponins were obtained from Solanum xanthocarpum fruits. Solasaponins A with the undescribed 16, 26-epoxy-furostanol carbon skeleton was disclosed. Some compounds revealed significant cytotoxic activity (＜10 μ M).