NIR-II imaging-guided diagnosis and evaluation of the therapeutic effect on acute alcoholic liver injury via a nanoprobe. Issue 19 (12th April 2022)

• Record Type: Journal Article
• Authors: Nie, Gang; Zhou, Yinxing; Song, Mengzi; Xu, Jingya; Cui, Zheng; Feng, Yangzhen; Wang, Huiling; Chen, Dugang; Zhang, Yu; Wang, Kaiping
• Is Part Of: Analytical methods. Volume 14:Issue 19(2022)
• Page Start: 1847
• Page End: 1855
• Publication Date: 2022-04-12
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/d2ay00279e
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : A NIR-II nanoprobe was developed and applied with excellent photostability and prominent biocompatibility to diagnose acute alcoholic liver injury in mice in vivo and evaluate the therapeutic effects of a drug on AALI mice by NIR-II imaging. Abstract : Acute alcoholic liver injury (AALI) is hard to diagnose on account of no obvious clinical symptoms, and thereby it easily develops into serious liver diseases and threatens people's health. However, traditional methods for detecting AALI are far from satisfactory due to the low sensitivity, invasiveness and non-visualization, and the development of new techniques is in urgent demand. Near-infrared (NIR)-II fluorescence imaging has been widely studied in biochemistry and biomedicine. As the blood flow velocity of the liver is closely related to the progression of AALI, herein, a NIR-II fluorescent nanoprobe, NTPB-NPs, was applied to diagnose AALI by monitoring the fluorescence intensity changes in the liver caused by the variations of the blood flow velocity. More importantly, when medication was applied to alleviate the liver injury of AALI mice, NTPB-NPs could also track the therapeutic effect in situ . In this study, the relationship between hepatic vascular velocity and the progression of AALI was confirmed with NTPB-NPs via NIR-II imaging. To the best of our knowledge, this is the first time that a NIR-II fluorescence imaging technique has been used to diagnose AALI mice and evaluate the therapeutic effect on AALI mice. This study may also provide a potential NIR-II imaging agent for clinical research to improve the management of liver injury related diseases.