STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma. (June 2022)

• Record Type: Journal Article
• Authors: Thakore, Pratish; Earley, Scott
• Is Part Of: Cell calcium. Volume 104(2022)
• Publication Date: 2022-06
• Subjects: Airway smooth muscle -- STIM1 -- Asthma; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2022.102589
• Languages: English
• ISSNs: 0143-4160

Abstract

Abstract: Airway smooth muscle remodeling and hyperresponsiveness are critical determinants of asthma severity, but the precise mechanisms regulating these disease processes remain elusive. In their latest study published in PNAS, Trebak and colleagues demonstrate that STIM1 (stromal-interacting molecule 1) expression is upregulated in airway smooth muscle cells during asthma and facilitates Ca 2+ influx to drive airway remodeling and hyperresponsiveness. Graphical abstract: Image, graphical abstract