Hybrid modelling of biological systems: current progress and future prospects. Issue 3 (30th March 2022)

• Record Type: Journal Article
• Authors: Liu, Fei; Heiner, Monika; Gilbert, David
• Is Part Of: Briefings in bioinformatics. Volume 23:Issue 3(2022)
• Publication Date: 2022-03-30
• Subjects: biological modelling -- hybrid modelling -- modelling formalisms; Genetics -- Data processing -- Periodicals; Molecular biology -- Data processing -- Periodicals; Genomes -- Data processing -- Periodicals; 572.80285
• DOI: 10.1093/bib/bbac081
• Languages: English
• ISSNs: 1467-5463

Abstract

Abstract: Integrated modelling of biological systems is becoming a necessity for constructing models containing the major biochemical processes of such systems in order to obtain a holistic understanding of their dynamics and to elucidate emergent behaviours. Hybrid modelling methods are crucial to achieve integrated modelling of biological systems. This paper reviews currently popular hybrid modelling methods, developed for systems biology, mainly revealing why they are proposed, how they are formed from single modelling formalisms and how to simulate them. By doing this, we identify future research requirements regarding hybrid approaches for further promoting integrated modelling of biological systems.