Manganese-catalyzed CH functionalizations driven via weak coordination: Recent developments and perspectives. (11th May 2022)

• Record Type: Journal Article
• Authors: Ali, Shaukat; Rani, Aneesa; Khan, Saifullah
• Is Part Of: Tetrahedron letters. Volume 97(2022)
• Publication Date: 2022-05-11
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153749
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Functional groups of common feedstock chemicals have been used efficiently as directing groups for sustainable manganese-catalyzed CH bond functionalization reactions. This approach is successfully applied in developing CH addition to oxiranes, imines, olefins, allylic electrophiles, azides, aldehydes and isocyanates via CC and CN bonds formation. In some cases reaction cascades resulting in annulated products have also been observed. Abstract: Weakly coordinating functional groups such as keto and ester of common feedstock chemicals have been used efficiently as directing groups for sustainable manganese-catalyzed CH bond functionalization reactions. This approach is successfully applied in developing CH addition to oxiranes, imines, olefins, allylic electrophiles, azides, aldehydes and isocyanates via CC and CN bonds formation. In some cases reaction cascades resulting in annulated products have also been observed. In this perspective we summarizes on the current developments in organometallic manganese-catalyzed CH functionalizations driven via weak coordination and have pointed out challenges/opportunities for future catalytic improvements. The mechanistic studies done so far on this emerging topic of manganese catalysis have revealed low valent (0 and +1) manganese complexes more efficient for these transformations.