Lung function and exercise capacity in prematurely born young people. Issue 9 (29th June 2020)

• Record Type: Journal Article
• Authors: Harris, Christopher; Lunt, Alan; Bisquera, Alessandra; Peacock, Janet; Greenough, Anne
• Is Part Of: Pediatric pulmonology. Volume 55:Issue 9(2020)
• Page Start: 2289
• Page End: 2295
• Publication Date: 2020-06-29
• Subjects: antenatal corticosteroids -- spirometry -- surfactant; Pediatric respiratory diseases -- Periodicals; Pediatrics -- Periodicals; 618.922
• DOI: 10.1002/ppul.24918
• Languages: English
• ISSNs: 8755-6863

Abstract

Abstract: Objectives: To determine if lung function abnormalities in young people born very prematurely routinely exposed to antenatal corticosteroids and postnatal surfactant were associated with reduced exercise capacity. Working Hypothesis: In the current era, lung function abnormalities would not be associated with exercise intolerance Study Design: Follow‐up of young people from the United Kingdom Oscillation study (UKOS). Patient‐Subject Selection: One hundred twenty‐six young people of 797 recruited to UKOS, born at a mean gestational age of 27 weeks were assessed at a mean age of 17 years. Methodology: Forced expiratory flow at 75% of the expired vital capacity (FEF75 ), forced expiratory volume in 1 second (FEV1 ) and lung volumes (forced vital capacity [FVC]) and residual volume (RV) and functional residual capacity (FRCpleth ) were assessed. Abnormal lung function was below the fifth centile and very abnormal lung function below the 2.5th centile. Exercise capacity was assessed using a modified shuttle sprint test and self‐reported hours of exercise. Results: Thirty‐nine young people had an abnormal FEF75 with an adjusted reduction in sprint distance of 114 m ( P = .018) and an adjusted difference in self‐reported exercise of 0.73 hours ( P = .036). Twenty‐seven young people had a very abnormal FEF75 with an adjusted reduction in sprint distance of 159 m ( P = .002) and adjusted reduction in self‐reported exercise of 1.15 hours ( P = .002). Conclusion: Very prematurely born young people with abnormal airway function had a significant reduction in exercise capacity.