Discordance Between Diagnosis Tools for Assessing Eczema in Infants: A Challenge for Intervention Trials. Issue 3 (16th May 2022)

• Record Type: Journal Article
• Authors: Pittet, Laure F.; Messina, Nicole L.; Gardiner, Kaya; Freyne, Bridget; Abruzzo, Veronica; Morrison, Clare; Vuillermin, Peter; Allen, Katrina J.; Ponsonby, Anne-Louise; Robins-Browne, Roy; Shann, Frank; Flanagan, Katie L.; Donath, Susan; Casalaz, Dan; Phillips, Rod; Curtis, Nigel
• Is Part Of: Dermatitis. Volume 33:Issue 3(2022)
• Page Start: 207
• Page End: 214
• Publication Date: 2022-05-16
• Subjects: Skin -- Inflammation -- Periodicals; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatitis, Contact -- Periodicals; Dermatitis, Atopic -- Periodicals; Dermatitis, Occupational -- Periodicals; Drug Eruptions -- Periodicals; 616.51
• DOI: 10.1097/DER.0000000000000842
• Languages: English
• ISSNs: 1710-3568

Abstract

Abstract : Background: There is no standardized definition for infant eczema, and various tools have been used across studies, precluding direct comparison. Objective: The aim of the study was to assess and to compare the accuracy of diagnostic tools for infant eczema using the extensive data collected in Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), an eczema prevention trial. Methods: Eczema incidence was assessed by 3 questionnaire-based measures: modified UK diagnostic tool, parent-reported medically diagnosed eczema, and parent-reported use of topical corticosteroids. Agreement between the definitions was quantified using κ coefficient. Eczema severity was assessed by 3-monthly Patient-Oriented Eczema Measure (POEM) scores and a SCORing Atopic Dermatitis (SCORAD) clinical assessment at a 12-month visit (ClinicalTrial.gov : NCT01906853). Results: Among the 538 participants fulfilling at least 1 of the 3 questionnaire-based eczema definitions, only 197 participants (37%) met all 3 definitions. Agreement between the definitions was poor with κ coefficients ranging from -0.11 to 0.62. The most frequently reported symptoms were generally dry skin (483/538, 90%) and pruritus (400/538, 74%). The face (352/538, 65%) and the trunk (306/538, 57%) were more frequently affected than the creases (257/538, 48%). Participants fulfilling all 3 questionnaire-based definitions of eczema were more likely to have higher severity scores and earlier onset of symptoms. Conclusions: There is poor agreement between currently available tools for assessing infant eczema.