Leukemic Presentation of Anaplastic Large Cell Lymphoma: A Diagnostic Challenge Mimicking T-Cell Prolymphocytic Leukemia. Issue 3 (May 2022)

• Record Type: Journal Article
• Authors: Vadasz, Brian; Wolniak, Kristy; Sukhanova, Madina; Chen, Yi-Hua; Behdad, Amir
• Is Part Of: AJSP reviews & reports. Volume 27:Issue 3(2022)
• Page Start: 119
• Page End: 122
• Publication Date: 2022-05
• Subjects: ALCL -- anaplastic large cell lymphoma -- leukemic phase; Pathology, Surgical -- Periodicals; Pathology, Surgical; Pathologie chirurgicale; Pathology, Surgical; Electronic journals; Periodicals; 617.07
• DOI: 10.1097/PCR.0000000000000511
• Languages: English
• ISSNs: 2381-5949

Abstract

Abstract: Anaplastic large cell lymphoma (ALCL) is a rare systemic T-cell neoplasm that typically involves nodal and extranodal sites and is further classified into 2 subgroups: anaplastic lymphoma kinase (ALK-) positive (ALK + ) and ALK-negative. Leukemic presentation of ALCL is extremely rare. Most cases with leukemic presentation are the small-cell variant of ALK + ALCL, are positive for the t(2;5)(p23;q35) translocation, and are associated with a poor prognosis. We report a case of ALK + ALCL that presented with a high white blood cell count and morphologic and phenotypic features resembling T-cell prolymphocytic leukemia.