Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Young Patients With a History of Migraine. Issue 6 (6th May 2022)

• Record Type: Journal Article
• Authors: van Os, Hendrikus J.A.; Verbaan, Dagmar; Ruigrok, Ynte M.; Dennesen, Paul; Müller, Marcella C.A.; Coert, Bert A.; Vergouwen, Mervyn D.I.; Wermer, Marieke J.H.
• Is Part Of: Stroke. Volume 53:Issue 6(2022)
• Page Start: 2075
• Page End: 2077
• Publication Date: 2022-05-06
• Subjects: epilepsy -- hospitals -- middle aged -- migraine disorders -- subarachnoid hemorrhage; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.121.038350
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Background: Young patients with aneurysmal subarachnoid hemorrhage (aSAH) and a history of migraine may have an increased risk of delayed cerebral ischemia. We investigated this potential association in a prospective cohort of aSAH patients under 50 years of age. Methods: In our prospective cohort study, we included patients with aSAH under 50 years of age from 3 hospitals in the Netherlands. We assessed lifetime migraine history with a short screener. Delayed cerebral ischemia was defined as neurological deterioration lasting >1 hour not attributable to other causes by diagnostic workup. Adjustments were made for possible confounders in multivariable Cox regression analyses, and adjusted hazard ratios were calculated. Results: We included 236 young aSAH patients (mean age, 41 years; 64% women) of whom 44 (19%) had a history of migraine (16 with aura). Patients with aSAH and a history of migraine were not at increased risk of developing delayed cerebral ischemia compared with patients without migraine (25% versus 20%; adjusted hazard ratio, 1.16 [95% CI, 0.57–2.35]). Additionally, no increased risk was found in migraine patients with aura (adjusted hazard ratio, 0.85 [95% CI, 0.30–2.44]) or in women (adjusted hazard ratio, 1.24 [95% CI, 0.58–2.68]). Conclusions: Patients with aSAH under the age of 50 years with a history of migraine are not at increased risk of delayed cerebral ischemia.