Clinical Utility of Repetitive Nerve Stimulation Test in Differentiating Multifocal Motor Neuropathy From Progressive Muscular Atrophy. Issue 4 (June 2022)

• Record Type: Journal Article
• Authors: Watanabe, Shunsuke; Sekiguchi, Kenji; Noda, Yoshikatsu; Matsumoto, Riki
• Is Part Of: Journal of clinical neuromuscular disease. Volume 23:Issue 4(2022)
• Page Start: 175
• Page End: 182
• Publication Date: 2022-06
• Subjects: repetitive nerve stimulation test -- multifocal motor neuropathy -- progressive muscular atrophy -- neuromuscular junction; Neuromuscular diseases -- Periodicals; 616.744005
• DOI: 10.1097/CND.0000000000000401
• Languages: English
• ISSNs: 1522-0443

Abstract

Abstract: Objectives: To evaluate the utility of repetitive nerve stimulation test (RNS) for differentiating multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA). Methods: We retrospectively enrolled 20 patients with MMN or PMA. We extracted the results of the initial 3-Hz RNS in the ulnar and accessory nerves and compared the percentage and frequency of abnormal decremental responses between both groups. Results: RNS was performed in 8 ulnar and 9 accessory nerves in patients with MMN, and in 8 ulnar and 10 accessory nerves in patients with PMA. Patients with MMN had a significantly lower decrement percentage (0.6 ± 4.0% in MMN vs. 10.3 ± 6.5% in PMA, P < 0.01) and frequency of abnormal decremental response (0 of 9 in MMN vs. 6 of 10 in PMA, P = 0.01) than patients with PMA in the accessory nerve. Conclusions: The RNS has clinical utility for differentiating MMN from PMA.