IRVAN syndrome: A case report and a literature review. (May 2022)

• Record Type: Journal Article
• Authors: Mansour, Marah; Al-Ghotani, Basel; Abo-Shdeed, Bana; Jannoud, Omaya
• Is Part Of: Annals of medicine and surgery. Volume 77(2022)
• Publication Date: 2022-05
• Subjects: Panretinal photocoagulation -- Fluorescein fundus angiography -- IRVAN syndrome -- Case report; IRVAN: Idiopathic Retinal Vasculitis, Aneurysms, And Neuroretinitis -- FFA: Fluorescein Fundus Angiography -- OCT: Optical Coherence Tomography -- PRP: Pan-Retinal Photocoagulation -- RPE: Retinal Pigment Epithelium -- FVP: Fibrovascular Proliferation -- RD: Retinal detachment -- ANA: Antinuclear Antibodies -- HLA-B51: Human Leukocyte Antigen B51 -- LE: Left Eye -- RE: Right Eye -- AFS: Allergic Fungal Sinusitis; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2022.103725
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Introduction and Importance: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a rare retinal defect. It has a female predominance. The staging of IRVAN was defined depending on ocular criteria. Case presentations: A 30-year-old female patient presented with floaters in the left eye. One year later, it was diagnosed with Fluorescein fundus angiography (FFA) at stage Ⅲ of IRVAN syndrome. After one year, the right eye was affected, diagnosed at stage Ⅱ, and successfully treated with heavy Pan-Retinal Photocoagulation (PRP). Clinical discussion: IRVAN Syndrome is an extremely rare retinal defect which has female predominance. The etiology of this syndrome still idiopathic. The most encountered symptoms are blurred vision and vision loss. FFA is the best diagnostic investigation to reveal the retinal abnormalities. Many suggested protocols were mentioned to treat IRVAN Syndrome. Our experience suggests IRVAN Syndrome a differential diagnosis for patients with floaters, and assures that PRP is an affective curement for late stages of IRVAN Syndrome. Conclusions: Heavy PRP was used successfully for stage II and III. The case emphasizes the importance of early diagnosis to assert the complications. Furthermore, IRVAN syndrome should be considered as a differential diagnosis in patients with floaters. Therefore, heavy PRP is highly recommended as a suitable treatment for IRVAN syndrome. Highlights: IRVAN Syndrome is a probable diagnosis for patients with floaters. Early diagnosis of IRVAN Syndrome has a significant effect on the treatment outcomes. IRVAN Syndrome may have genetic etiologies. Pan lateral photocoagulation may be efficient even in late stages.