Ibrutinib-associated dermatologic toxicities: A systematic review and meta-analysis. (June 2022)

• Record Type: Journal Article
• Authors: Nocco, Sarah; Andriano, Tyler M.; Bose, Arpita; Chilov, Marina; Godwin, Kendra; Dranitsaris, George; Wu, Shenhong; Lacouture, Mario E.; Roeker, Lindsay E.; Mato, Anthony R.; Markova, Alina
• Is Part Of: Critical reviews in oncology/hematology. Volume 174(2022)
• Publication Date: 2022-06
• Subjects: Ibrutinib -- Dermatology -- Cutaneous -- Adverse event -- Management -- Dermatologic adverse events -- Toxicity -- Kinase inhibitor -- Bruton's tyrosine kinase -- BTK inhibitor; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2022.103696
• Languages: English
• ISSNs: 1040-8428

Abstract

Abstract: The scope of dermatologic adverse events to ibrutinib has not been systematically described. We sought to determine the incidence and severity of ibrutinib-associated dermatologic toxicities and provide management recommendations. We conducted a systematic literature search of clinical trials and cohorts investigating ibrutinib monotherapy for cancer or chronic graft-versus-host disease through June 2020. Thirty-two studies with 2258 patients were included. The incidence of all-grade toxicities included cutaneous bleeds (24.8%; 95%CI, 18.6–31.0%), mucocutaneous infections (4.9%; 95%CI, 2.9–7.0%), rash (10.8%; 95%CI. 6.1–15.5%), mucositis (6%; 95%CI, 3.6–8.5%), edema (15.9%; 95%CI, 11.1–20.6%), pruritus (4.0%; 95%CI, 0.0–7.9%), xerosis (9.2%; 95%CI, 5.5–13.0%), nail changes (17.8%; 95%CI, 4.1–31.5%), and hair changes (7.9%; 95%CI, 0.0–21.3%). The incidence of high-grade toxicities included mucocutaneous infection (1.3%; 95%CI, 0.5–2.2%), rash (0.1%; 95%CI, 0.0–0.2%), mucositis (0.1%; 95%CI, 0.0–0.3%), and edema (0.1%; 95%CI, 0.0–0.2%). It is imperative that clinicians familiarize themselves with ibrutinib-associated dermatologic toxicities to learn how to manage them, prevent discontinuation, and improve patient outcomes. Graphical Abstract: ga1 Highlights: Ibrutinib-associated dermatologic toxicities are common Toxicities included cutaneous bleeds, mucocutaneous infections, and nail changes High-grade toxicities included mucocutaneous infections, rash, mucositis, and edema Toxicity identification and management are needed to improve patient outcomes