CCAAT enhancer binding protein gamma (C/EBP-γ): An understudied transcription factor. (May 2022)

• Record Type: Journal Article
• Authors: Renfro, Zachary; White, Bryan E.; Stephens, Kimberly E.
• Is Part Of: Advances in biological regulation. Volume 84(2022)
• Publication Date: 2022-05
• Subjects: Transcription factor -- CCAAT-Enhancer binding protein -- Integrated stress response -- Cancer -- Cell proliferation -- Neuronal development; AML acute myeloid leukemia -- ATF activating transcription factor -- bZIP leucine zipper -- CCL5 CC-chemokine ligand 5 -- C/EBP CCAAT enhancer binding -- ISR integrated stress response -- LPS lipopolysaccharide -- NK natural killer; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2022.100861
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: The CCAAT enhancer binding protein (C/EBP) family of transcription factors are important transcriptional mediators of a wide range of physiologic processes. C/EBP- γ is the shortest C/EBP protein and lacks a canonical activation domain for the recruitment of transcriptional machinery. Despite its ubiquitous expression and ability to dimerize with other C/EBP proteins, C/EBP- γ has been studied far less than other C/EBP proteins, and, to our knowledge, no review of its functions has been written. This review seeks to integrate the current knowledge about C/EBP- γ and its physiologic roles, especially in cell proliferation, the integrated stress response, oncogenesis, hematopoietic and nervous system development, and metabolism, as well as to identify areas for future research.