Biocompatibility and nanostructured materials: applications in nanomedicine. (19th May 2017)

• Record Type: Journal Article
• Authors: Adabi, Mahdi; Naghibzadeh, Majid; Adabi, Mohsen; Zarrinfard, Mohammad Ali; Esnaashari, Seyedeh Sara; Seifalian, Alexander M.; Faridi-Majidi, Reza; Tanimowo Aiyelabegan, Hammed; Ghanbari, Hossein
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 4(2017)
• Page Start: 833
• Page End: 842
• Publication Date: 2017-05-19
• Subjects: Biocompatibility -- blood brain barrier -- immune response -- nanomaterials -- polymer -- toxicity; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2016.1178134
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: There has been huge interest in applications of nanomaterials in biomedical science, including diagnosis, drug delivery, and development of human organs. Number of these nanomaterials has been already studied in human or at pre-clinical trial. There is a growing concern on potential toxicity and adverse effects of nanomaterials on human health, including lack of standard method of assessment of toxicology of these materials. Our investigation indicated that the bare and small nanoparticle have higher toxicity than modified and bulk materials, respectively. In addition, spherical nanoparticles have less toxicity than rod nanoparticles due to immune response of body.