The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock. (19th May 2017)

• Record Type: Journal Article
• Authors: Zhao, Jing; Yan, Chengbin; Xu, Lijuan; Yan, Kunping; Feng, Bao; Zhao, Mengye; Niu, Geng; Wu, Mengdi; Chen, Chao; Zhu, Hongli
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 45:Number 4(2017)
• Page Start: 677
• Page End: 685
• Publication Date: 2017-05-19
• Subjects: Polymerized porcine hemoglobin -- hemorrhagic shock -- hemodynamic stability -- mesenteric microcirculation; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2017.1282869
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: The effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and maintenance of mesenteric microvascular function were explored in a rat model of hemorrhagic shock (HS). Following controlled hemorrhage, rats were infused with equal volumes of either pPolyHb, hetastarch (HES), or red blood cell (RBC). The results showed that pPolyHb was superior to HES and RBC in restoring hemodynamic stability and reversing anaerobic metabolism. We observed a reduction in the diameter of mesenteric microvasculature after HS. Resuscitation with pPolyHb and RBC was able to restore the diameters of the venules and arterioles, whereas HES failed to restore the diameters during the observation period.