Cov19VaxKB: A web-based integrative COVID-19 vaccine knowledge base. (April 2022)

• Record Type: Journal Article
• Authors: Huang, Philip C.; Goru, Rohit; Huffman, Anthony; Yu Lin, Asiyah; Cooke, Michael F.; He, Yongqun
• Is Part Of: Vaccine. Volume 10(2022)
• Publication Date: 2022-04
• Subjects: Vaccine -- SARS-CoV-2 -- COVID-19 -- COVID-19 vaccine -- Database -- Knowledge base -- Bioinformatics -- Adverse event -- VAERS -- Cov19VaxKB -- Ontology; AE adverse event -- CDC Centers for Disease Control and Prevention -- COVID-19 Coronavirus disease 2019 -- FDA Food and Drug Administration -- MERS-CoV Middle Eastern Respiratory Syndrome -- NCBI National Center for Biotechnology Information -- PMID PubMed identification number -- PRR Proportional Reporting Ratio -- OWL Web Ontology Language -- SARS-CoV Severe Acute Respiratory Syndrome Coronavirus -- SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2 -- VAERS Vaccine Adverse Event Reporting System -- VIOLIN Vaccine Investigation and Online Information Network -- VO Vaccine Ontology -- WHO World Health Organization
• DOI: 10.1016/j.jvacx.2021.100139
• Languages: English
• ISSNs: 2590-1362

Abstract

Abstract: The development of SARS-CoV-2 vaccines during the COVID-19 pandemic has prompted the emergence of COVID-19 vaccine data. Timely access to COVID-19 vaccine information is crucial to researchers and public. To support more comprehensive annotation, integration, and analysis of COVID-19 vaccine information, we have developed Cov19VaxKB, a knowledge-focused COVID-19 vaccine database (http://www.violinet.org/cov19vaxkb/ ). Cov19VaxKB features comprehensive lists of COVID-19 vaccines, vaccine formulations, clinical trials, publications, news articles, and vaccine adverse event case reports. A web-based query interface enables comparison of product information and host responses among various vaccines. The knowledge base also includes a vaccine design tool for predicting vaccine targets and a statistical analysis tool that identifies enriched adverse events for FDA-authorized COVID-19 vaccines based on VAERS case report data. To support data exchange, Cov19VaxKB is synchronized with Vaccine Ontology and the Vaccine Investigation and Online Information Network (VIOLIN) database. The data integration and analytical features of Cov19VaxKB can facilitate vaccine research and development while also serving as a useful reference for the public.