CHANGES IN CHORIOCAPILLARIS, SATTLER, AND HALLER LAYER THICKNESSES IN CENTRAL SEROUS CHORIORETINOPATHY AFTER HALF-FLUENCE PHOTODYNAMIC THERAPY. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Flores-Moreno, Ignacio; Arcos-Villegas, Gabriel; Sastre, Marina; Ruiz-Medrano, Jorge; Arias-Barquet, Luis; Duker, Jay S.; Ruiz-Moreno, José M.
• Is Part Of: Retina. Volume 40:Issue 12(2020)
• Publication Date: 2020-12
• Subjects: central serous chorioretinopathy -- choriocapillaris -- choroid -- choroidal thickness -- optical coherence tomography -- photodynamic therapy; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002764
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To determinate the variation in thickness of the individual choroidal layers in patients with central serous chorioretinopathy treated with half-fluence photodynamic therapy. Methods: Twenty-two eyes were evaluated with spectral-domain optical coherence tomography. The images were taken before photodynamic therapy, 3 months, and 6 months after the treatment. Two investigators performed these measurements: 1) choroidal thickness (CT), 2) Haller layer thickness, defined as the most external layer containing a 100- μ m vessel, and 3) choriocapillaris + Sattler layer (C&S). Nine measurements were taken in the macular region. Results: Choroidal thickness before photodynamic therapy was 471.8 µ m ± 145.8. The Haller layer was 358.4 µ m ± 122.6, and C&S was 114.3 µ m ± 27.8. At 3-month follow-up, CT was 441.1 µ m ± 150.7, Haller layer 348.8 µ m ± 127.6, and C&S 92.4 µ m ± 27.9. At 6-month follow-up, CT was 420.4 µ m ± 118.4, Haller layer 331.8 µ m ± 97.2, and C&S 89.5 µ m ± 28.0. Using a multilevel mixed-effects linear regression, CT was found to be reduced at both 3 months ( P < 0.03) and at 6 months ( P < 0.001), Haller layer showed no significant reduction at 3 months ( P = 0.483) or at 6 months ( P = 0.055), and C&S showed reduction at 3 months ( P < 0.001) and at 6 months ( P < 0.001). Fellow nonaffected eyes showed no statistical variation at 3-month and 6-month follow-up. Conclusion: Reduction in CT in patients affected by central serous chorioretinopathy after half-fluence photodynamic therapy occurs primarily in the choriocapillaris and medium diameter vessel layers of the choroid in a short- and medium-term follow-up. Abstract : Half-fluence photodynamic therapy, in patients affected by central serous chorioretinopathy, results in a reduction in thickness of choriocapillaris and Sattler layer in a 6-month follow-up.