ALTERED BLOOD AND AQUEOUS HUMOR LEVELS OF ASPROSIN, 4-HYDROXYNONENAL, AND 8-HYDROXY-DEOXYGUANOSINE IN PATIENTS WITH DIABETES MELLITUS AND CATARACT WITH AND WITHOUT DIABETIC RETINOPATHY. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Oruc, Yavuz; Celik, Fatih; Ozgur, Gokhan; Beyazyildiz, Emrullah; Ugur, Kader; Yardim, Meltem; Sahin, Ibrahim; Akkoc, Ramazan Fazil; Aydin, Suleyman
• Is Part Of: Retina. Volume 40:Issue 12(2020)
• Publication Date: 2020-12
• Subjects: asprosin -- 4-hydroxynonenal -- 8-hydroxy-2′-deoxyguanosine -- diabetic retinopathy -- aqueous humor -- cataract; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002776
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: Diabetic retinopathy (DRP) is the formation of edema and small vessels in the retina due to high blood glucose levels. Asprosin is a hormone that stimulates the release of glucose from the liver into the circulation. Considering the relationship between oxidative stress and DRP, our study aimed to determine the levels of the oxidative stress markers 4-hydroxynonenal (4-HNE) and 8-hydroxy-2′-deoxyguanosine (8-OHdG), as well as asprosin, in the blood and aqueous humor (Aq) of patients with and without DRP. Methods: Thirty patients with single-eye DRP and cataract (DRP + C), 30 patients with diabetes mellitus and cataract without DRP (DM + C), and 30 healthy control (CON) participants were enrolled into this retrospective study. Except for healthy controls, Aq and blood samples were taken from these patients during their cataract operation. Asprosin, 4-HNE, and 8-OHdG concentrations were analyzed using enzyme-linked immunosorbent assays. Results: In patients with DRP, the levels of asprosin, 4-HNE, and 8-OHdG were significantly higher in both Aq and blood samples compared with the group of patients without DRP. Conclusion: These findings suggest that the measurement of asprosin, 4-HNE, and 8-OHdG levels may support clinicians in determining the risk of DRP development. Abstract : Aqueous humor and blood levels of asprosin, 4-hydroxynonenal, and 8-hydroxy-2′-deoxyguanosine in patients with diabetic retinopathy and cataract are higher than in patients with diabetes mellitus and cataract. These could be a new metabolic indicator of this disease.