Prenatal exposure to polycyclic aromatic hydrocarbons and gestational age at birth. (June 2022)

• Record Type: Journal Article
• Authors: Freije, Sophia L.; Enquobahrie, Daniel A.; Day, Drew B.; Loftus, Christine; Szpiro, Adam A.; Karr, Catherine J.; Trasande, Leonardo; Kahn, Linda G.; Barrett, Emily; Kannan, Kurunthachalam; Bush, Nicole R.; LeWinn, Kaja Z.; Swan, Shanna; Alex Mason, W.; Robinson, Morgan; Sathyanarayana, Sheela
• Is Part Of: Environment international. Volume 164(2022)
• Publication Date: 2022-06
• Subjects: Polycyclic aromatic hydrocarbons (PAH) -- Maternal exposure -- Gestational age -- Preterm birth -- Sex-specific associations; OH-PAH Monohydroxylated polycyclic aromatic hydrocarbons -- PTB Preterm Birth -- GA gestational age -- CANDLE Conditions Affecting Neurocognitive Development and Learning in Early Childhood -- TIDES The Infant Development and Environment Study -- GAPPS Global Alliance to Prevent Prematurity and Stillbirth -- 1-OH-NAP 1-hydroxynaphthalene -- 2-OH-NAP 2-hydroxynaphthalene -- 2-OH-PHEN 2-hydroxyphenanthrene -- 3-OH-PHEN 3-hydroxyphenanthrene -- 1/9-OH-PHEN combined 1- and 9-hydroxyphenanthrene -- 2/3/9-OH-FLUO combined 2-, 3-, and 9-hydroxyfluorene -- 1-OH-PYR 1-hydroxypyrene -- OR Odd's Ratio -- CI Confidence Interval; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2022.107246
• Languages: English
• ISSNs: 0160-4120

Abstract

Graphical abstract: Highlights: We examined overall and sex-specific associations of prenatal PAH with GA at birth. The study population was a large and geographically diverse longitudinal cohort. PAH exposure was not associated with spontaneous PTB in the pooled population. Higher prenatal OH-NAP was associated with earlier GA at birth. Females may be more susceptible to PTB or shorter GA following prenatal PAH exposure. Abstract: Background: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous chemicals with mechanisms of toxicity that include endocrine disruption. We examined associations of prenatal urinary PAH with spontaneous preterm birth (PTB) and gestational age (GA) at birth. We also assessed whether infant sex modifies the association of PAH exposure with spontaneous PTB and GA at birth. Methods: Participants included 1, 677 non-smoking women from three cohorts (CANDLE, TIDES, and GAPPS) in the ECHO PATHWAYS Consortium. Twelve monohydroxylated-PAHs were measured in second trimester maternal urine. Seven metabolites with >60% overall detection were included in analyses: 1-hydroxynaphthalene [1-OH-NAP], 2-hydroxynaphthalene [2-OH-NAP], 2-hydroxyphenanthrene [2-OH-PHEN], 3-hydroxyphenanthrene [3-OH-PHEN], 1/9-hydroxyphenanthrene [1/9-OH-PHEN], 2/3/9-hydroxyfluorene [2/3/9-OH-FLUO], and 1-hydroxypyrene [1-OH-PYR]. Logistic and linear regression models were fit for spontaneous PTB and GA among births ≥34 weeks, respectively, with log10 -transformed OH-PAH concentrations as the exposure, adjusted for specific gravity and suspected confounders. Effect modification by infant sex was assessed using interaction terms and marginal estimates. Results: Percent detection was highest for 2-OH-NAP (99.8%) and lowest for 1-OH-PYR (65.2%). Prevalence of spontaneous PTB was 5.5% (N = 92). Ten-fold higher 2-OH-NAP exposure was associated with 1.60-day (95% CI: −2.92, −0.28) earlier GA at birth. Remaining associations in the pooled population were null. Among females, we observed significant inverse associations between 1-OH-PYR and PTB (OR: 2.65 [95% CI: 1.39, 5.05]); and 2-OH-NAP with GA: −2.46 days [95% CI: −4.15, −0.77]). Among males, we observed an inverse association between 2/3/9-OH-FLUO and PTB (OR = 0.40 [95% CI: 0.17, 0.98]). ORs for PTB were higher among females than males for 2-OH-PHEN (p = 0.02) and 1-OH-PYR (p = 0.02). Discussion: We observed inverse associations of 2-OH-NAP exposure with GA and null associations of remaining OH-PAHs with GA and PTB. Females may be more susceptible to spontaneous PTB or shorter GA following prenatal exposure to some OH-PAHs. This study is the first to assess sex-specific OH-PAH toxicity in relation to spontaneous PTB and GA.