Plasmonic photoreactors-coated plastic tubing as combined-active-and-passive antimicrobial flow sterilizer. Issue 12 (2nd March 2022)

• Record Type: Journal Article
• Authors: An, Xingda; Cheng, Ronghai; Liu, Pinghua; Reinhard, Björn M.
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 12(2022)
• Page Start: 2001
• Page End: 2010
• Publication Date: 2022-03-02
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb02250d
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Plasmonic photoreactor nanocomposite coating provides both active and passive antibacterial properties to plastic surfaces. Abstract : Plastic materials are ubiquitous in medical devices and consumer goods. As bacterial contamination of plastic surfaces can pose significant health risks, there is a need for effective approaches both to inactivate bacteria on plastic surfaces and to prevent colonization of plastic surfaces. In this study, we evaluate a plasmonic photoreactor coating for plastic surfaces that provides both active and passive antimicrobial effects and implement a visible light-driven antibacterial flow sterilizer. We demonstrate that this approach inactivates bacteria in an aqueous suspension passed through a photoreactor-coated polyethylene tubing, achieving log reduction values (LRVs) > 5 for both Gram-positive and -negative bacteria under resonant LED illumination. Importantly, the antimicrobial flow sterilizers do not cause a detectable loss of functionality for monoclonal antibodies that were included in this work as an example of high-value biologics that require sterilization. Under ambient light illumination, the plasmonic photoreactor coating exhibits a significant inhibitory effect on bacterial colonization and biofilm formation. The inhibitory effect was substantially weaker for mammalian cells, indicating some selectivity in the protection provided by the coating.