A new era in oxygen therapeutics? From perfluorocarbon systems to haemoglobin-based oxygen carriers. (July 2022)

• Record Type: Journal Article
• Authors: Charbe, Nitin B.; Castillo, Francisco; Tambuwala, Murtaza M.; Prasher, Parteek; Chellappan, Dinesh Kumar; Carreño, Aurora; Satija, Saurabh; Singh, Sachin Kumar; Gulati, Monica; Dua, Kamal; González-Aramundiz, José Vicente; Zacconi, Flavia C.
• Is Part Of: Blood reviews. Volume 54(2022)
• Publication Date: 2022-07
• Subjects: Blood transfusion -- Perfluorocarbons (PFCs) -- Haemoglobin-based oxygen carriers (HBOCs) -- Nitric oxide scavenging -- Vasoconstriction -- Recombinant haemoglobin; ATP adenosine triphosphate -- B-PEG-Hb bovine pegylated-haemoglobin -- bis-Mal-PEG2000 bis(maleidophenyl)-PEG2000 -- CO carbon monoxide -- CO2 carbon dioxide -- DBBF bis-(3, 5-dibromosalicyl)-fumarate -- deoxyHb deoxyhaemoglobin -- DPG diphosphoglycerate -- DPPC 2-dipalmitoyl-sn-glycero-3-phosphatidylcholine -- EAF extension arm facilitated -- E. coli Escherichia coli -- FDA Food and Drug Administration -- GU-HP-Hb glutaraldehyde-polymerized human placenta haemoglobin -- Hb haemoglobin or hemoglobin -- HBOC haemoglobin-based oxygen carrier -- HBOCs haemoglobin-based oxygen carriers -- HIF-⍺ hypoxia-inducible factor 1-alpha -- HIF-β hypoxia-inducible factor 1-beta -- HO-1 heme oxygenase-1 -- IgM immunoglobin M -- LHb liposome-encapsulated haemoglobin -- MAP mean arterial pressure -- MNBs micro-nanobubbles -- MnCO3 manganese carbonate -- MP4CO pegylated human haemoglobin-based carbon monoxide -- mPEG-PLA-mPEG methoxy poly(ethylene glycol)-b-poly(L-lactide) -- N2 nitrogen gas -- NFPLP 2-nor-2-formylpyridoxal phosphate -- NO nitric oxide -- O2 oxygen gas -- O-R-Hb O-raffinose cross-linked haemoglobin -- oxyHb oxyhaemoglobin -- p50 oxygen half-saturation -- PC phosphatidylcholine -- PEG poly(ethylene glycol) -- PEG-COHb carboxy form of poly(ethylene glycol)-haemoglobin -- PEG-DSPE 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) -- PEG-Hb poly(ethylene glycol)-haemoglobin -- PFC perfluorocarbon -- PFCs perfluorocarbons -- PLA polylactic acid -- PLGA polylactic-co-glycolic acid -- PolyHeme® human polymerized haemoglobin -- PPHb polynitroxylated PEGylated haemoglobin -- pPolyHb glutaraldehyde-polymerized porcine haemoglobin -- PS phosphatidylserine -- RBC red blood cells -- rHb recombinant haemoglobin -- rHb 1.1 first generation of recombinant haemoglobin -- rHb 2.0 second generation of recombinant haemoglobin -- TLR4 toll-like receptor 4 -- Val valine -- ZO-1 zonula occludens-1 or tight junction protein-1.; Hematology -- Periodicals; Hematology -- Periodicals; Hématologie -- Périodiques; Hematology; Electronic journals; Periodicals; 616.15
• DOI: 10.1016/j.blre.2022.100927
• Languages: English
• ISSNs: 0268-960X

Abstract

Abstract: Blood transfusion is the key to life in case of traumatic emergencies, surgeries and in several pathological conditions. An important goal of whole blood or red blood cell transfusion is the fast delivery of oxygen to vital organs and restoration of circulation volume. Whole blood or red blood cell transfusion has several limitations. Free haemoglobin not only loses its tetrameric configuration and extracts via the kidney leading to nephrotoxicity but also scavenges nitric oxide (NO), leading to vasoconstriction and hypertension. PFC based formulations transport oxygen in vivo, the contribution in terms of clinical outcome is challenging. The oxygen-carrying capacity is not the only criterion for the successful development of haemoglobin-based oxygen carriers (HBOCs). This review is a bird's eye view on the present state of the PFCs and HBOCs in which we analyzed the current modifications made or which are underway in development, their promises, and hurdles in clinical implementation. Graphical abstract: The present state of potential oxygen carriers from perfluorocarbons to haemoglobin-based systems is presented where we analyzed the current modifications made or underway in its development, their promises, and hurdles in clinical implementation. Unlabelled Image