Association of HLA-DR1, HLA-DR13, and HLA-DR16 Polymorphisms with Systemic Lupus Erythematosus: A Meta-Analysis. (16th April 2022)

• Record Type: Journal Article
• Authors: Wang, Tingrui; Wang, Hong; Qiu, Lijuan; Wu, Lingling; Ling, Huayun; Xue, Yu; Zhou, Ying; Chen, Huijuan; Ye, Dong-Qing; Wang, Bin
• Other Names: Ciccacci Cinzia Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2022(2022)
• Publication Date: 2022-04-16
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2022/8140982
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : Objectives . The principal purpose of this meta-analysis was to assess the association between HLA-DRB1 (HLA-DR1, HLA-DR13, and HLA-DR16) polymorphisms and SLE susceptibility. Methods . We searched published case-control studies on the association between HLA-DRB1 polymorphisms and SLE susceptibility from PubMed and Web of Science databases. The pooled ORs with 95% CIs were utilized to estimate the strength of association of HLA-DR1, HLA-DR13, and HLA-DR16 polymorphisms and SLE susceptibility by fixed effect models. We also performed sensitivity analysis, trial sequential analysis, Begg's test, and Egg's test in this meta-analysis. Results . A total of 18 studies were included in this meta-analysis. Overall analysis showed that HLA-DR1 and HLA-DR13 polymorphisms were associated with a decreased risk of SLE (OR = 0.76, 95% CI: 0.65-0.90, P < 0.01 ; OR = 0.58, 95% CI: 0.50-0.68, P < 0.01 ), and HLA-DR16 polymorphism was associated with an increased risk of SLE (OR = 1.70, 95% CI: 1.24-2.33, P < 0.01 ). In subgroup analysis of ethnicity, the results were as follows: HLA-DR1 polymorphism in Caucasians (OR = 0.76, 95% CI: 0.58-0.98, P = 0.04 ) and North Americans (OR = 0.64, 95% CI: 0.42-0.96, P = 0.03 ); HLA-DR13 polymorphism in Caucasians (OR = 0.62, 95% CI: 0.47-0.82, P < 0.01 ) and East Asians (OR = 0.44, 95% CI: 0.34-0.57, P < 0.01 ); and HLA-DR16 polymorphism in East Asians (OR = 2.62, 95% CI: 1.71-4.03, P < 0.01 ). Conclusions . This meta-analysis showed that HLA-DR1 and HLA-DR13 are protective factors for SLE, and HLA-DR16 is a risk factor. Due to the limitations of this meta-analysis, the association between HLA-DRB1 polymorphisms and SLE susceptibility needs to be further researched before definitive conclusions are proved.