Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Beltrán-García, Jesús; Osca-Verdegal, Rebeca; Pallardó, Federico V.; Ferreres, José; Rodríguez, María; Mulet, Sandra; Ferrando-Sánchez, Carolina; Carbonell, Nieves; García-Giménez, José Luis
• Is Part Of: Critical care medicine. Volume 48:Issue 12(2020)
• Publication Date: 2020-12
• Subjects: anti-inflammatory therapy -- cytokine storm -- sepsis -- severe acute respiratory syndrome coronavirus 2; Critical care medicine -- Periodicals; Soins intensifs -- Périodiques; 616.028
• DOI: 10.1097/CCM.0000000000004625
• Languages: English
• ISSNs: 0090-3493

Abstract

Abstract : Great efforts are being made worldwide to identify the specific clinical characteristics of infected critically ill patients that mediate the associated pathogenesis, including vascular dysfunction, thrombosis, dysregulated inflammation, and respiratory complications. Recently, coronavirus disease 2019 has been closely related to sepsis, which suggests that most deaths in ICUs in infected patients are produced by viral sepsis. Understanding the physiopathology of the disease that lead to sepsis after severe acute respiratory syndrome coronavirus 2 infection is a current clinical need to improve intensive care–applied therapies applied to critically ill patients. Although the whole representative data characterizing the immune and inflammatory status in coronavirus disease 2019 patients are not completely known, it is clear that hyperinflammation and coagulopathy contribute to disease severity. Here, we present some common features shared by severe coronavirus disease 2019 patients and sepsis and describe proposed anti-inflammatory therapies for coronavirus disease 2019 which have been previously evaluated in sepsis.