Death in a farmer with underlying diseases carrying Vibrio cholerae non-O1/non-O139 producing zonula occludens toxin. (July 2022)

• Record Type: Journal Article
• Authors: Zhao, Ying; He, Tingting; Tu, Bowen; Mao, Xujian; Jiang, Jingyi; Jiang, Xia; Wang, Fengming; Wang, Min; Wang, Yu; Sun, Hongyan
• Is Part Of: International journal of infectious diseases. Volume 120(2022)
• Page Start: 83
• Page End: 87
• Publication Date: 2022-07
• Subjects: Non-O1/non-O139 Vibrio cholerae -- Zonula occludens toxin (Zot) -- pre-CTX Φ -- ST271 -- Underlying diseases -- Hypervirulence -- MLST; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2022.04.020
• Languages: English
• ISSNs: 1201-9712

Abstract

Abstract: Objectives: The non-O1/non-O139 Vibrio cholerae caused outbreaks or sporadic cases of gastroenteritis that was rarely seen in good sanitary condition. It was described a case of systemic multiple organ lesions that worsened because of non-O1/non-O139 V. cholerae, suggesting that serogroups have a potential virulence in enhancing pathogenicity with patients with underlying diseases compared with a healthy population. Design or methods: Samples are identified by strain culture, polymerase chain reaction (PCR) virulence identification, and whole genome sequencing. Results: A middle-aged man was diagnosed with cytotoxin-producing and nontoxin V. cholerae non-O1/non-O139 serogroups. Although lacking the CT toxin encoded by ctxAB gene, the pathogenesis of cholera relies on the synergistic action of many other genes, especially virulence genes. Conclusions: This case suggested that the laborers engaging in agricultural production are at potential risk of V. cholerae infection by exposure of open wounds to contaminated water . However, epidemiological investigation should focus on the objective cause of the change of working environment. Furthermore, common diseases can possibly enhance the virulence of non-O1/non-O139 serogroups by attacking the tight junction of small intestinal epithelial cells, further triggering bacteremia, a process that may lead to death within 48–72 hours, which requires great attention.