Neuroprotective effects of aromatic turmerone on activity deprivation-induced apoptosis in cerebellar granule neurons. Issue 18 (16th December 2020)

• Record Type: Journal Article
• Authors: Saga, Yuya; Hatakenaka, Yudai; Matsumoto, Miho; Yoshioka, Yuri; Matsumura, Shinichi; Zaima, Nobuhiro; Konishi, Yoshiyuki
• Is Part Of: NeuroReport. Volume 31:Issue 18(2020)
• Publication Date: 2020-12-16
• Subjects: apoptosis -- ar-turmerone -- caspase-3 -- cerebellar granule neurons -- Curcuma longa; Neurosciences -- Periodicals; Nervous system -- Periodicals; Neurophysiology -- Periodicals; Nervous System Diseases -- Periodicals; Nervous System Physiological Phenomena -- Periodicals; Neurosciences -- Periodicals; 616.805
• DOI: 10.1097/WNR.0000000000001551
• Languages: English
• ISSNs: 0959-4965

Abstract

Abstract : Ar-turmerone, which is a major bioactive component found in the essential oil derived from Curcuma longa, has been reported to inhibit proliferation and induce apoptosis in cancer cell lines. Recently, ar-turmerone has been reported to increase the proliferation of neuronal stem cells, in contrast to its actions in cancer cells. These observations raise the possibility that ar-turmerone serves specific functions in neuronal cell lineages. However, the effects of ar-turmerone on postmitotic neurons remain elusive. In the present study, we investigated the neuroprotective functions of ar-turmerone in primary cerebellar granule neuronal cultures. We found that ar-turmerone increased the survival of neurons following activity deprivation. Consistently, the induction of cleaved caspase-3, a hallmark of apoptosis, was prevented by ar-turmerone, although neither the level of reactive oxygen species nor the mitochondrial membrane potential was affected. This study reports a neuroprotective function for ar-turmerone, providing new insights into the potential therapeutic applications of ar-turmerone for neurological disorders.