Electrospinning of ampicillin trihydrate loaded electrospun PLA nanofibers I: effect of polymer concentration and PCL addition on its morphology, drug delivery and mechanical properties. Issue 9 (13th June 2022)

• Record Type: Journal Article
• Authors: Eren Boncu, Tugba; Ozdemir, Nurten
• Is Part Of: International journal of polymeric materials. Volume 71:Issue 9(2022)
• Page Start: 669
• Page End: 676
• Publication Date: 2022-06-13
• Subjects: Ampicillin trihydrate -- electrospinning -- HFIP (1, 1, 1, 3, 3, 3-Hexafluoro-2-propanol) -- nanofiber -- PCL (polycaprolactone) -- PLA (polylactic acid) -- PLA/PCL nanofiber; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2021.1876057
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: It was aimed to produce ampicillin trihydrate loaded electrospun PLA and PLA/PCL nanofibers using HFIP as solvent. The effect of PLA concentration (7.5–12.5%), PCL addition and added PCL amount (20–80%) on the nanofibers properties were investigated. The increase in PLA concentration caused an increase in nanofiber diameter and a decrease in mechanical properties. PLA nanofibers have shown biphasic controlled drug release up to 10 days, while PCL nanofiber caused only a rapid burst effect. As a result, PLA concentration and the amount of added PCL affected the average nanofiber diameter, in vitro drug release and mechanical properties of the obtained electrospun nanofibers. Graphical Abstract: UF0001